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<title>IRis</title>
<copyright>Copyright (c) 2013 Northeastern University All rights reserved.</copyright>
<link>http://iris.lib.neu.edu</link>
<description>Recent documents in IRis</description>
<language>en-us</language>
<lastBuildDate>Sat, 18 May 2013 01:34:07 PDT</lastBuildDate>
<ttl>3600</ttl>


	
		
	

	
		
	

	
		
	

	
		
	

	
		
	

	
		
	

	
		
	

	
		
	

	
		
	

	
		
	

	
		
	

	
		
	

	
		
	

	
		
	







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<title>Rational design and synthesis of amplified therapeutic/diagnostic agents targeting the estrogen receptor</title>
<link>http://iris.lib.neu.edu/chemistry_theses/28</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/chemistry_theses/28</guid>
<pubDate>Fri, 17 May 2013 13:37:36 PDT</pubDate>

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		<p>Estradiol tolerates the presence of large functional groups off of the 11-beta position while retaining a reasonable relative binding affinity to Estrogen Receptor-alpha; (ER-alpha). Although RU 39,4112, a prototypical 11-beta substituted estradiol derivative, has been considered as a potent therapeutic anti-estrogen, it also has the potential for serving as a highly ER-selective targeting agent. Because there is over-expression of ER in breast cancer cells, it is a logical biological target for compounds like RU 39,411 or its analogs. In this study, I will apply this information to design and synthesize a novel and selective delivery system for breast cancer tumor...
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<author>Anton Igorevich Kozhushnyan</author>


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<title>Spectral cytopathology: a dagnostic tool for the oral cavity and the esophagus</title>
<link>http://iris.lib.neu.edu/chemistry_theses/27</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/chemistry_theses/27</guid>
<pubDate>Fri, 17 May 2013 08:35:14 PDT</pubDate>

	<description>
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		<p>Spectral cytopathology (SCP), which couples Fourier Transform infrared micro-spectroscopy (IR-MSP) with unsupervised multivariate statistical methods, is an accurate and robust optical tool for the detection of subtle biochemical changes that occur within individual cells. SCP monitors the biochemical composition of cells within a sample and through computer-based algorithms is able to identify and classify unique spectral changes that are induced by disease. These subtle molecular changes can be observed before morphological changes become apparent, allowing earlier diagnostic information to become available for cytologists. When diagnostic information is available earlier the patient can potentially be offered treatment more swiftly, thus improving...
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<author>Kathleen Lenau</author>


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<title>Mass spectrometric analysis of therapeutic proteins and complex biological samples</title>
<link>http://iris.lib.neu.edu/chemistry_diss/66</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/chemistry_diss/66</guid>
<pubDate>Thu, 16 May 2013 12:54:55 PDT</pubDate>

	<description>
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		<p>Recombinant DNA technology has been widely used for therapeutic protein production in pharmaceutical industry. In order to enhance product yield and efficiency, investigations and studies have been made to understand of host cell culture transcriptomics, proteomics and metabolomics. The protein product is expressed together with a complex mixture of host cell proteins from cell cultures. As a result of the variability of the cellular production process and following manufacturing stages, protein drugs are heterogeneous because of post-translational modifications (PTMs) as well as sequence variants. Comprehensive analyses of protein drugs as well as the complex biological system during the manufacturing procedures...
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<author>Suli Liu</author>


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<title>Activation of phenotypic subpopulations in response to ciprofloxacin treatment in acinetobacter baumannii</title>
<link>http://iris.lib.neu.edu/biology_theses/25</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/biology_theses/25</guid>
<pubDate>Thu, 16 May 2013 12:28:48 PDT</pubDate>

	<description>
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		<p>The desiccation-resistant pathogen, <em>Acinetobacter baumannii</em>, has spread swiftly through hospitals worldwide. Favoring chromosomal insertions and rearrangements, <em>A. baumannii</em> isolates are quickly becoming pandrug resistant. We have recently demonstrated that <em>A. baumannii</em> regulates the expression of multiple copies of genes encoding error-prone DNA polymerases, which seem to be responsible for DNA damage- or desiccation-induced mutagenesis, leading to antibiotic resistance. Here, we explore expression of the DNA damage-inducible system in <em>A. baumannii</em>, using transcriptional reporters fused to green fluorescent protein for selected DNA damage response genes. The expression of these genes in response to treatment with the antibiotic, ciprofloxacin, was then analyzed...
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<author>Ashley Erin MacGuire</author>


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<title>Design, fabrication and assembly of multiple biomarker in-vivo biosensor</title>
<link>http://iris.lib.neu.edu/elec_eng_diss/70</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/elec_eng_diss/70</guid>
<pubDate>Thu, 16 May 2013 11:40:39 PDT</pubDate>

	<description>
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		<p>High sensitivity and high specificity detection of disease biomarkers is crucial for early diagnostics and monitoring of diseases. Current cancer diagnostics tools are invasive and uncomfortable. Blood tests that are currently being used also lack sufficient sensitivity and specificity for early detection of diseases. In this thesis, a design for highly sensitive micron scale in-vivo sensor platform device for simultaneous detection of multiple disease biomarkers is presented. The biosensor microchip is 0.25mm in diameter, based on SU-8 polymeric platform fabricated incorporating four active isolated areas as small as 70µm x 70µm. Conventional micro and nanofabrication processes were used for fabrication...
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<author>Asanterabi Malima</author>


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<title>Towards rare-earth-free permanent magnets: exchange bias in binary Mn-based alloys</title>
<link>http://iris.lib.neu.edu/chemical_eng_theses/13</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/chemical_eng_theses/13</guid>
<pubDate>Thu, 16 May 2013 07:33:15 PDT</pubDate>

	<description>
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		<p>Quantum–mechanical exchange interactions between phases in ferromagnetic/antiferromagnetic (FM/AF) magnetic nanocomposite systems can result in useful effects such as exchange bias (<em>H</em><sub>ex</sub>) and remanence enhancement. These effects are more pronounced in nanostructured systems than in their coarse–grained counterparts due to improved interphase contact and can be developed to create good permanent magnetic behavior, but are currently poorly understood in bulk three–dimensional systems. To achieve this goal, factors such as the magnetic and structural phase identity, chemistry, size, shape, and character are investigated. To this end, synthesis, characterization and analysis of the magnetic and structural properties of nanocomposites are carried out on...
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<author>Joshua Marion</author>


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<title>Northeastern University Law Magazine, 2013 Winter</title>
<link>http://iris.lib.neu.edu/nu_law_mag/19</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/nu_law_mag/19</guid>
<pubDate>Wed, 15 May 2013 13:58:22 PDT</pubDate>


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<author>Northeastern University - School of Law</author>


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<title>Heterogeneous nanostructure flexible hybrid quasi solid-state supercapacitor based on vertical aligned carbon nanotubes and carbon nanocups</title>
<link>http://iris.lib.neu.edu/mech_eng_theses/72</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/mech_eng_theses/72</guid>
<pubDate>Wed, 15 May 2013 12:36:22 PDT</pubDate>

	<description>
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		<p>High performance heterogeneous hybrid structure quasi solid-state electric double-layer capacitors (supercapacitors) have been developed by assembling two morphologically different nano-engineered carbon electrodes. The perfect interaction between these two graphitic materials, such as vertically aligned carbon nanotubes (VA-CNTs) and high porous carbon nanocups (CNC), permit the realization of a very thin film supercapacitor with a high frequency response, low internal resistance and high performance. Additionally, the traditional dielectric layer (separator) has been removed and has been replaced with a combination of gel electrolyte and an ionic liquid polymer membrane, provides an innovative design to the quality of the quasi solid-state device....
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<author>Fabrizio Martini</author>


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<title>Using second harmonic generation microscopy to study the three-dimensional structure of collagen and its degradation mechanism</title>
<link>http://iris.lib.neu.edu/elec_eng_diss/69</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/elec_eng_diss/69</guid>
<pubDate>Wed, 15 May 2013 12:06:08 PDT</pubDate>

	<description>
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		<p>Collagen is one of the most abundant proteins found in the human body. Its crystalline structure possesses no centrosymmetry, allowing it to emit second-harmonic waves. Second harmonic generation (SHG) microscopy utilizes the latter quality to produce high-resolution images of collagen rich tissues and therefore become a key research tool in the biomedical field. We developed a new model, intended to be used together with second harmonic generation (SHG) microscopy, to thoroughly investigate collagen-based tissues. We use our SHG model to reveal information in real time from enzymatic biochemical processes. We also present a novel method used to measure quantitatively the...
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<author>Yair Mega</author>


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<title>Research on development and application of simulated night vision enhancement systems</title>
<link>http://iris.lib.neu.edu/mech_eng_diss/48</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/mech_eng_diss/48</guid>
<pubDate>Tue, 14 May 2013 13:50:20 PDT</pubDate>

	<description>
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		<p>Poor visibility due to darkness is believed to be one of the main causes for the high rate of night driving accidents.</p> <p>Night vision enhancement systems (NVESs) have been developed to improve visibility at night through supplementing drivers' direct vision with additional information shown on a display, rather than replacing drivers' direct vision. Existing studies have shown that NVESs may increase recognition distance, but may also increase drivers' mental and visual distraction (eyes-off-road). Each scan of the display of the night vision enhancement system involves some visual and mental cost to the driver. Automatic pedestrian warnings (APWs) have been integrated...
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<author>Linzhen Nie</author>


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<title>Exploiting temporal and spatial correlation in wireless sensor networks</title>
<link>http://iris.lib.neu.edu/elec_comp_theses/108</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/elec_comp_theses/108</guid>
<pubDate>Tue, 14 May 2013 12:09:24 PDT</pubDate>

	<description>
		<![CDATA[
		<p>Collecting data continuously from Wireless Sensor Networks (WSNs) with limited power and bandwidth is a challenging problem. Such networks have potential utility in a wide range of disciplines such as medical, industrial, environmental, and military applications. For long-term monitoring and surveillance applications, the objective is often times to cover as large an area as possible while still acquiring high-resolution information about the sensed environment. The main challenges involve energy-efficiency and scalability of the techniques used to acquire the substantial amount of data from the sensor network. Addressing these challenges, we propose a method that effectively exploits both spatial and temporal...
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<author>Daniel Parker</author>


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<title>The role of seasonality, seaweed traits, and seaweed-herbivore interactions in nutrient cycling in the southern Gulf of Maine</title>
<link>http://iris.lib.neu.edu/biology_theses/24</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/biology_theses/24</guid>
<pubDate>Tue, 14 May 2013 11:42:56 PDT</pubDate>

	<description>
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		<p>Environmental fluctuations associated with both natural events and anthropogenic impacts can appreciably alter the functioning of ecosystems. For example, in the Gulf of Maine, there is substantial spatial and temporal variation in availability of nutrients that fuel primary production. Macroalgae are important primary producers in intertidal and shallow benthic habitats, and they play essential roles in absorbing nutrients (e.g., inorganic C, N, and P) and mediating their availability (e.g., as organic C, N, and P) to the communities that they support. The ability of macroalgae to take up nutrients depends on nutrient availability. However, sometimes a nutrient in short supply...
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<author>Valerie Catlin Perini</author>


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<title>Learning informal interaction: the problem of self-help literature for expression games</title>
<link>http://iris.lib.neu.edu/criminal_justice_theses/4</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/criminal_justice_theses/4</guid>
<pubDate>Tue, 14 May 2013 10:17:15 PDT</pubDate>

	<description>
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		<p>The goal of many self-help books on interpersonal relationships is for the reader to learn how to "just act natural." There are certain processes that interfere with one's ability to follow such advice, namely, the imposition of calculation of what is `natural' will not generate a reality where the "just natural" interaction that is occurring is believed. This thesis examines several implications of this as it relates to the social organization of experience and the limitations of self-help books in aiding in the learning production of that experience of expression games in informal interaction. These implications and limitations are examined...
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<author>Michael Wesley Raphael</author>


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<title>Third way poets: navigating the streams of modern and postmodern poetic uncertainty</title>
<link>http://iris.lib.neu.edu/english_diss/17</link>
<guid isPermaLink="true">http://iris.lib.neu.edu/english_diss/17</guid>
<pubDate>Mon, 13 May 2013 10:07:03 PDT</pubDate>

	<description>
		<![CDATA[
		<p>This dissertation examines the career arcs of four representative current poets in order to develop a tentative narrative to account for recent and emergent poetic practice. Poets who began publishing between the 1970s and 1990s inherited two powerful aesthetic traditions. On the one hand, they write in the shadow of postmodern poets who find liberation in the embrace of radical linguistic, epistemological/ontological, or subjective uncertainty and exhibit intense skepticism about intellectual closure or claims of privilege for aesthetic production. On the other hand, they also find aesthetic reserves in the work of high modernists who felt they faced similar philosophical...
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<author>James A. Richie</author>


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