We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
coupled dynamics, transmembrane voltage, paced cardiac cells, biological physics
Intracellular calcium, Heart cells, Biophysics
Shiferaw, Yohannes; Sato, Daisuke; and Karma, Alain, "Coupled dynamics of voltage and calcium in paced cardiac cells" (2005). Physics Faculty Publications. Paper 83. http://hdl.handle.net/2047/d20000436
Click button above to open, or right-click to save.