Abstract

We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.

Notes

Originally posted at http://arxiv.org/abs/physics/0405048v1. Preprint of an article published in Physical Review E, v.71 no.2, 2005.

Keywords

coupled dynamics, transmembrane voltage, paced cardiac cells, biological physics

Subject Categories

Intracellular calcium, Heart cells, Biophysics

Disciplines

Physics

Publication Date

2005

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Physics Commons

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