Abstract
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
Keywords
coupled dynamics, transmembrane voltage, paced cardiac cells, biological physics
Subject Categories
Intracellular calcium, Heart cells, Biophysics
Disciplines
Physics
Publication Date
2005
Permanent URL
Recommended Citation
Shiferaw, Yohannes; Sato, Daisuke; and Karma, Alain, "Coupled dynamics of voltage and calcium in paced cardiac cells" (2005). Physics Faculty Publications. Paper 83. http://hdl.handle.net/2047/d20000436
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Notes
Originally posted at http://arxiv.org/abs/physics/0405048v1. Preprint of an article published in Physical Review E, v.71 no.2, 2005.