Taslim, Mohammad E.
Advances in chromatographic systems have led to progressively smaller packing materials in the analytical columns. The decrease in the size of critical components within these columns has increased the risk for premature failure due to clogging by bacteria growing in the aqueous solvents. The development of a device for reduction or elimination of the microorganisms by disinfection, filtration or sterilization of these solutions is desired. Product design requirements were established in conjunction with the sponsor, Waters Corporation. Several design concepts were the result of research into patents and other literature and were analyzed based on design goals and requirements to determine the preferred approach. Further research determined that the best approach for a prototype is a device that combines ultraviolet radiation with filtration. The main components of the prototype will include: a dual-head pump for the purpose of running multiple sterilization lines, an ultraviolet radiation lamp which will mitigate bacterial growth, and a filter with an effective area to remove the dead bacteria and any particulates over the course of one year. Analysis is presented for the design and specification of each of these components. A summary of proof-of-concept test results is given, and recommendations for continuation of development and further testing are discussed.
chromatographic systems, prototype
Northeastern University, Department of Mechanical, Industrial and Manufacturing Engineering
Roulleau, Nicolas; Vose, Michael; Racette, Michael; and McKay, Michael, "Sterilization Device for Liquid Chromotography Solvents" (2007). Capstone Design Program: Mechanical Engineering. Paper 96. http://hdl.handle.net/2047/d1001150x
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