Our solutions to verify the system sterilization temperature field and eliminate seal failure in the Microfluidics M710 Microfluidizer Processor are described in this document. The Microfluidizer is a device that breaks product particles into uniform nanoparticles. The system is modeled using GAMBIT and analyzed using Fluent. This simulation will allow us to predict the pressures and temperatures across the entire system. The temperature and pressure are not able to be measured in many parts of the system because it can not be broken to add thermal couples. A Fluent simulation is one of the only ways to verify temperature in many locations. This data will enable us to alter the inlet temperature to ensure that all parts of the system will reach 121 degrees Celsius as defined by ASME standard BPE-a- 2004 but will not become so hot that the seals in the intensifier pump fail.
microfluidizer, Fluent simulation
Northeastern University, Department of Mechanical, Industrial and Manufacturing Engineering
Lototski, Matt; Humphreys, Jared; Bradley, Colin; Arena, Mike; and Chaplin, John, "Microfluidics Sterilization System" (2007). Capstone Design Program: Mechanical Engineering. Paper 78. http://hdl.handle.net/2047/d10011560
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