Abstract
Drug resistance is problematic in microbial disease, viral disease and cancer. Understanding at the outset that resistance will impact the effectiveness of any new drug that is developed for these disease categories is imperative. In this Perspective, we detail approaches that have been taken with selected drug targets to reduce the susceptibility of new drugs to resistance mechanisms. We will also define the concepts of robust drugs and resilient targets, and discuss how the design of robust drugs and the selection of resilient targets may lead to successful strategies for combating resistance.
Keywords
drug resistance, drug development
Subject Categories
Drug resistance, Drug development
Disciplines
Pharmaceutics and Drug Design
Publisher
Elsevier Ltd.
Publication Date
7-19-2011
Rights Information
Copyright 2011
Rights Holder
Elsevier Ltd.
Permanent URL
Recommended Citation
Schiffer, Celia; Anderson, Amy C.; Pollastri, Michael P.; and Peet, Norton P., "The challenge of developing robust drugs to overcome resistance" (2011). Chemistry and Chemical Biology Faculty Publications. Paper 3. http://hdl.handle.net/2047/d20002076
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Notes
NOTICE: this is the author’s version of a work that was accepted for publication in Drug Discovery Today. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Drug Discovery Today, v.16 no.17-18, September 2011, pp. 755-761. DOI:10.1016/j.drudis.2011.07.001