Alternate Title

Reconstruction of Spatially Resolved Pharmacokinetic Rate Imaging of Optical Flurophores from NIR

Abstract

This paper investigates the pharmacokinetics of the optical contrast agent indocyanine green (ICG) as a malignancy indicator for breast cancer. Several authors have conducted optical measurements using Indocyanine green (ICG) in animal models (Colacino, Cuccia, Gurfinkel) and human patients (Colacino, Edwards, Ntziachristos, Intes, Nioka, and others). These results suggest clinical utility of ICG as a kinetic agent. Here, we present data collected with near infrared optical devices as part of a continuing study on breast cancer patients. Additionally, we have histopathological data on lesions clinically proven to be suspicious and information from several other diagnostic modalities. We investigate four, three and two-compartment models for ICG kinetics in animal and breast tumors. Our results from Fischer rat data analysis indicate that two-compartment model is sufficient and that ICG pharmacokinetics can distinguish between different tumor types.

Notes

Poster presented at the 2006 Thrust R2A Multi-View Tomographic Models Conference

Keywords

ICG, Breast tumors, histopathology, Pharmacokinetic

Subject Categories

Diagnostic imaging

Disciplines

Biomedical Engineering and Bioengineering

Publisher

Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems (Gordon-CenSSIS)

Publication Date

2006

Rights Holder

Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems (Gordon-CenSSIS)



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