Copyright (c) 2013 Northeastern University All rights reserved. http://iris.lib.neu.edu/cdd_fac_pubs Recent documents in Center for Drug Discovery Faculty Publications en-us Sun, 27 Jan 2013 23:05:04 PST 3600 http://iris.lib.neu.edu/cdd_fac_pubs/2 http://iris.lib.neu.edu/cdd_fac_pubs/2 Wed, 08 Aug 2012 12:35:43 PDT Characterization of intrinsic and extrinsic factors regulating the self-renewal/division and differentiation of stem cells is crucial in determining embryonic stem (ES) cell fate. ES cells differentiate into multiple hematopoietic lineages during embryoid body (EB) formation in vitro, which provides an experimental platform to define the molecular mechanisms controlling germ layer fate determination and tissue formation. Methods and Findings. The cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2) are members of the G-protein coupled receptor (GPCR) family, that are activated by endogenous ligands, the endocannabinoids. CB1 receptor expression is abundant in brain while CB2 receptors are mostly expressed... ]]> Shuxian Jiang Cannabinoids - Receptors Embryonic stem cells http://iris.lib.neu.edu/cdd_fac_pubs/1 http://iris.lib.neu.edu/cdd_fac_pubs/1 Mon, 23 Apr 2012 13:05:20 PDT Over the last decade there have been significant advances in the discovery and understanding of the cannabinoid system along with the development of pharmacologic tools that modulate its function. Characterization of the crosstalk between nicotine addiction and the cannabinoid system may have significant implications on our understanding of the neurobiological mechanisms underlying nicotine dependence. Two types of cannabinoid receptors (CB1 and CB2) have been identified. CB1 receptors are expressed in the brain and modulate drug taking and drug seeking for various drugs of abuse, including nicotine. CB2 receptors have been recently identified in the brain and have been proposed to... ]]> Islam Gamaleddin Cannabinoids - Receptors Nicotine addiction