M. V. Sitkovskiĭ
Wendy A. Smith, Donald M. O'Malley
Date of Award
Master of Science
Department or Academic Unit
College of Arts and Sciences. Department of Biology.
Biology, Immune system, T cells, Hypoxia, Cancer, Hypersensitivity, Vaccines
Cancer vaccines, Immunologic diseases
Immunology of Infectious Disease
The immune system, when appropriately regulated, helps protect and defend the body from a variety of threats including pathogens, injuries, diseases, and cancer. However, not all immune responses are beneficial--an overactive immune response can cause more harm than the provoking agent, often resulting in considerable tissue damage. The hypoxia-adenosinergic pathway plays a crucial role in the regulation of T cell responses, by studying this pathway we can learn more about manipulating the immune system and develop better therapeutic strategies. Here we studied the delayed-type hypersensitivity response (DTH), long term immunization, modified air pouch, and intradermal tumor models on mice to gain understanding of the how to adjust the immune system through the hypoxia-adenosinergic mechanism. The preliminary data support the approach where different stages of the immune responses can be rationally manipulated by ""low-tech"" treatments like high oxygen and the A2A adenosine receptor antagonist, caffeine.
Margaret Ellen McCrann
McCrann, Margaret Ellen, "In vivo studies of the hypoxia-adenosinergic tissue protection mechanism" (2008). Biology Master's Theses. Paper 5. http://hdl.handle.net/2047/d10016612
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